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Product Prescribing Information
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CEVITIL


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  • Prescription Information
  • Composition            

     

    Each effervescent tablet contains: 
    Ascorbic acid ......................................................................................... 1 g
    Inactive ingredients: 

    Sodium bicarbonate, citric acid anhydrous, saccharin sodium, riboflavin sodium phosphate, sorbitol powder, lemon flavor, and povidone K30.

                                                                

    Therapeutic Indications        

           

    Treatment and prevention of vitamin C deficiency.
    Prophylaxis and treatment of scurvy.
    Methemoglobinemia.
    Promoting wound healing.
    Common cold, influenza, and other infectious diseases.
    Dental caries and bleeding gums.
    Adjuvant in the treatment of iron deficiency anaemia.
    As a dietary supplement.

                                                             

    Dosage and Administration          

                       

    1-2 Cevitil Effervescent Tablets daily.
    One effervescent tablet is dissolved in a half a glass of water, given as effervescent syrup of a pleasant taste.

                                                                 

    Contraindications           

                    

    Hypersensitivity to ascorbic acid.

                                                            

    Warnings and Precautions            

                     

    Cevitil should be given with caution to patients with hyperoxaluria or renal insufficiency.
    In diabetic patients, Cevitil should be discontinued for several days before determination of the glucose content in urine.
    Excessive doses of Cevitil should be avoided in: 
    Diabetic patients.
    Patients on sodium-restricted diet or anticoagulant therapy.
    Patients undergoing tests for occult blood in stools.
    Patients with G6PD deficiency, because large doses of ascorbic acid leads to hemolysis.

    Smokers appear to have increased requirements of ascorbic acid because the vitamin is oxidized and excreted more rapidly than in non smokers. So smokers having ascorbic acid deficiency should decrease or stop smoking.

                                                                   

    Drug Interactions       

               

    Salicylates:  Salicylates inhibit ascorbic acid uptake by leukocytes and platelets.
    Warfarin:  Ascorbic acid may inhibit it’s anticoagulant effect.
    Disulfiram:  Large doses of ascorbic acid may diminish the effect of disulfiram.
    Iron:  Ascorbic acid increases iron absorption in the gastrointestinal tract.

                                                              

    Pregnancy and Lactation       

                   

    Cevitil is not recommended during pregnancy, unless it is clearly needed, and it should be used with caution during lactation.

                                                                   

    Undesirable Effects          

                   

    Cevitil is usually well-tolerated.
    Large doses may cause nausea, vomiting, diarrhoea, heartburn, abdominal cramps, dizziness, and hemolysis in patients with glucose–6-phosphate dehydrogenase deficiency.

                                                                 

    Pharmacological Properties     

              

    Cevitil is a water-soluble vitamin, with antioxidant properties. It is essential for the synthesis of collagen and intercellular materials.
    Cevitil is also needed for healing process, and enhancing body resistance to infections.
    Pharmacokinetics:
    Ascorbic acid is readily absorbed from the gastrointestinal tract and is widely distributed in the body tissues, and crosses the placenta and appears in breast milk.
    Ascorbic acid is reversibly oxidized in the liver to dehydroascorbic acid, which is biologically active, some is metabolized to ascorbate-2-sulfate, which is inactive, and oxalic acid which are excreted in the urine. Ascorbic acid in excess of the body’s needs is also rapidly eliminated unchanged in the urine.

                                                           

    Storage              

             

    Store at a temperature not exceeding 25ºC.

                                                               

    Packaging


    Cevitil 1 g Effervescent Tablets:  Tube of 12 effervescent tablets.




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