Composition              

Each 1 ml contains:
Calcium chloride dihydrate ........................................................ 100 mg

Therapeutic Indications            

Hypocalcemia.
Electrolyte depletion.
Cardiac arrest.
Hyperkalemia.
Hypermagnesemia.

Dosage and Administration          

Adults: 
Hypocalcemia and Electrolyte depletion: 
Intravenous 500 mg to 1 g administered slowly at a rate not to exceed 0.5 ml to 1 ml per minute. The dose can be repeated at 1-3-days intervals according to serum calcium concentrations.
Cardiac arrest: 
Intravenous 500 mg to 1 g administered at a rate not to exceed 1 ml per minute.
Intraventricular, 200 mg-400 mg administered directly into cavity as a single dose.
Hyperkalemia: 
Dosage must be titrated by constant monitoring of E.C.G. changes during administration.
Hypermagnesenia: 
Intravenous 500 mg, repeated as indicated by patient response.
Pediatrics:
 Hypocalcemia:
Intravenous 25 mg/kg.

Contraindications         

As for all parenteral calcium salts, digitatis toxicity and ventricular fibrillation during cardiac resuscitation.

Warnings and Precautions     

Calcium chloride is irritant and cause necrosis if Injected I.M..

Drug Interactions                 

Concurrent use of parenteral calcium salts with digitalis may increase the risk of cardiac arrhythmias.
Parenteral calcium salts may neutralize effects of parenteral magnesium sulfate.
Parenteral calcium salts reverse the effects of non-depolarizing neuromuscular blocking agents.
Parenteral calcium salts should be administered cautiously in patients receiving potassium-containing medications because of danger of precipitating cardiac arrhythmias.

Pregnancy and Lactation       

Pregnancy:
studies have not been done in either animals or humans.
Lactation:
 It is not known whether calcium chloride is excreted in breast milk . 

Undesirable Effects         

 Intravenous administration may cause flushing, nausea, vomiting, sweating, skin rash, hypotension and irregular heart beats.

Pharmacological Properties 

Calcium is essential for the functional integrity of the nervous, muscular and skeletal systems.
It plays a role in normal cardiac function, renal function, respiration, blood coagulation and cell membrane and capillary permeability.
When there is disturbance in the calcium balance due to any cause, the stores of calcium in bone may be depleted to fill the body's more acute needs.

Packaging                 

CALCIUM CHLORIDE Ampoules: Boxes containing 5, 10, 50, or 100 ampoules of 5 and 10 ml each.